[Humoral and cell-mediated immune responses in humans to the A/California/07/ 2009 (H1N1) virus, A(H1N1)pdm2009].
Identifieur interne : 000215 ( 1957/Analysis ); précédent : 000214; suivant : 000216[Humoral and cell-mediated immune responses in humans to the A/California/07/ 2009 (H1N1) virus, A(H1N1)pdm2009].
Auteurs : A N Na Khin ; S A Donina ; G D Petukhova ; E M Koren'Kov ; E M Doroshenko ; E P Grigor'Eva ; M A Suvorova ; L G RudenkoSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (immunologie), Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (génétique), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Immunité cellulaire, Immunité humorale, Lymphocytes B (immunologie), Lymphocytes T (immunologie), Mâle, Mémoire immunologique (génétique), Mémoire immunologique (immunologie), Pandémies, Russie, Réactions croisées (génétique), Réactions croisées (immunologie), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- génétique : Grippe humaine, Mémoire immunologique, Réactions croisées, Sous-type H1N1 du virus de la grippe A.
- immunologie : Anticorps antiviraux, Grippe humaine, Lymphocytes B, Lymphocytes T, Mémoire immunologique, Réactions croisées, Sous-type H1N1 du virus de la grippe A.
- épidémiologie : Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Immunité cellulaire, Immunité humorale, Mâle, Pandémies, Russie, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral (immunology), B-Lymphocytes (immunology), Child, Child, Preschool, Cross Reactions (genetics), Cross Reactions (immunology), Female, Humans, Immunity, Cellular, Immunity, Humoral, Immunologic Memory (genetics), Immunologic Memory (immunology), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (genetics), Influenza, Human (immunology), Male, Middle Aged, Pandemics, Russia, T-Lymphocytes (immunology).
- MESH :
- chemical , immunology : Antibodies, Viral.
- geographic : Russia.
- epidemiology : Influenza, Human.
- genetics : Cross Reactions, Immunologic Memory, Influenza A Virus, H1N1 Subtype, Influenza, Human.
- immunology : B-Lymphocytes, Cross Reactions, Immunologic Memory, Influenza A Virus, H1N1 Subtype, Influenza, Human, T-Lymphocytes.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Immunity, Cellular, Immunity, Humoral, Male, Middle Aged, Pandemics.
Abstract
During the twentieth century the world faced four influenza A pandemics: A (H1N1) in 1918, A (H2N2) in 1957, A (H3N2) in 1957 and A (H1N1) recirculation in 1977. In the beginning of 2009 the global spread of A(H1N1)pdm2009 virus was detected. In consideration of clinical evidences and genetic data analysis WHO declared as the novel pandemic of 21th century. However, the fact of exceedingly prolonged previous worldwide circulation of A (H1N1) influenza viruses was not taken into account. Further development showed epidemiological prognosis not to be accurate enough. The present work is an attempt to analyze this question from the immunological standpoint based on our studies of antibody and cellular immunity to A(H1N1)pdm2009 virus in vaccinated and non-vaccinated persons of different ages. The study results allow concluding that A(H1N1)pdm2009 is the drift variant of A (H1N1) viruses antigenically close to A/Swine/1976/1931 (H1N1). It was shown that the significant of persons have cross-reactive B and T cell immunological memory to A(H1N1)pdm2009 strain. This could be a reason of decreased A(H1N1)pdm2009 pandemic severity.
PubMed: 23785769
Affiliations:
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pubmed:23785769Le document en format XML
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xml:lang="en">During the twentieth century the world faced four influenza A pandemics: A (H1N1) in 1918, A (H2N2) in 1957, A (H3N2) in 1957 and A (H1N1) recirculation in 1977. In the beginning of 2009 the global spread of A(H1N1)pdm2009 virus was detected. In consideration of clinical evidences and genetic data analysis WHO declared as the novel pandemic of 21th century. However, the fact of exceedingly prolonged previous worldwide circulation of A (H1N1) influenza viruses was not taken into account. Further development showed epidemiological prognosis not to be accurate enough. The present work is an attempt to analyze this question from the immunological standpoint based on our studies of antibody and cellular immunity to A(H1N1)pdm2009 virus in vaccinated and non-vaccinated persons of different ages. The study results allow concluding that A(H1N1)pdm2009 is the drift variant of A (H1N1) viruses antigenically close to A/Swine/1976/1931 (H1N1). It was shown that the significant of persons have cross-reactive B and T cell immunological memory to A(H1N1)pdm2009 strain. This could be a reason of decreased A(H1N1)pdm2009 pandemic severity.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Donina, S A" sort="Donina, S A" uniqKey="Donina S" first="S A" last="Donina">S A Donina</name><name sortKey="Doroshenko, E M" sort="Doroshenko, E M" uniqKey="Doroshenko E" first="E M" last="Doroshenko">E M Doroshenko</name><name sortKey="Grigor Eva, E P" sort="Grigor Eva, E P" uniqKey="Grigor Eva E" first="E P" last="Grigor'Eva">E P Grigor'Eva</name><name sortKey="Koren Kov, E M" sort="Koren Kov, E M" uniqKey="Koren Kov E" first="E M" last="Koren'Kov">E M Koren'Kov</name><name sortKey="Na Khin, A N" sort="Na Khin, A N" uniqKey="Na Khin A" first="A N" last="Na Khin">A N Na Khin</name><name sortKey="Petukhova, G D" sort="Petukhova, G D" uniqKey="Petukhova G" first="G D" last="Petukhova">G D Petukhova</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name><name sortKey="Suvorova, M A" sort="Suvorova, M A" uniqKey="Suvorova M" first="M A" last="Suvorova">M A Suvorova</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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